Suspension Chemistry

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Suspension

Suspension to contribute to animal studies

Before pulverizing Phenytoin After pulverizing Phenytoin
Phenytoin original bulk
(average particle size: about 10μm)
Pulverized Phenytoin bulk
(average particle size: about 100nm)
Evaluation by XRD Evaluation by DCS
Evaluation by XRD
(Powder X-ray diffraction)
Evaluation by DCS
(Differential scanning calorimetry)

SEM images of phenytoin that is a poor water soluble drug are presented in bulk powder and as processed by the nano pulverizer NP-100. The SEM images reveal that the micro level phenytoin bulk powder has been pulverized into a nano level size. XRD and DSC also indicate that the crystalline nature of phenytoin had been retained after the pulverization and no amorphous had been generated.

<References>
Takatsuka, T., Tomoko, E., Yao, J., Kayo, Y and Naofumi., H : Nanosizing Poorly Water Soluble Compounds Using Rotation/Revolution Mixer Chem. Pharm. Bull. 57(10) 1061--1067 (2009)

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